Medicina di Precisione, prevenzione, terapie e follow-up: le Malattie Croniche non trasmissibili (MCNT) una sfida per la salute del XXI secolo
Le Malattie Croniche non Trasmissibili (MCNT) sono la principale causa di morte in Italia, responsabili del 70% dei decessi. Patologie come malattie cardiovascolari, tumori e diabete rappresentano una sfida crescente per il sistema sanitario, impegnando l’80% del budget.
In Italia le Malattie Croniche non Trasmissibili (MCNT) sono prevalentemente patologie croniche multifattoriali ritenute responsabili del 70% dei decessi totali registrati.
In particolare, le malattie cardiovascolari, i tumori, le malattie respiratorie croniche, malattie metaboliche, patologie muscoloscheletriche sono da anni la principale causa di morte e sono ad alto impatto economico sui sistemi sociosanitari di tutto il Mondo.
In Italia le MCNT rappresentano oltre il 75% delle malattie globali e impegnano circa l’80% del budget totale sanitario che i paesi europei spendono per la tutela della salute, Italia compresa.
I dati già allarmanti sono destinati a peggiorare se non si realizzano strategie assistenziali e politiche sanitarie di contrasto basate oltre che su una corretta prevenzione e sul miglioramento di cure più efficaci anche su programmi educazionali intesi a limitare le principali cause determinanti le Malattie Croniche non Trasmissibili (MCNT) lo afferma Augusto Sannetti Presidente della Società Italiana Educazionale Medicina di Precisione in corso della conferenza stampa per la presentazione del “XXIV Congresso Nazionale di Bari” del 18/19 Ottobre p.v. presieduto dal Prof. Piero Portincasa Professore Ordinario di Medicina Interna, Direttore Clinica Medica A. Murri, Dipartimento di Medicina di Precisione e Rigenerativa e Area Ionica (DiMePre-J) Università degli Studi di Bari “Aldo Moro”.
Recentemente l’OMS (Organizzazione Mondiale della Sanità) ha identificato nella sorveglianza uno dei pilastri fondamentali per qualsivoglia strategia contro l’MCNT che insieme ad un adeguato monitoraggio, prevenzione e cura può diminuire il numero enorme dei decessi precoci e migliorare la qualità della vita di milioni di persone in Italia.
Le Malattie Croniche non Trasmissibili (MCNT) sono malattie a lungo termine e sono generalmente causate da fattori di rischio come l’età, la genetica, lo stile di vita, l’ambiente ed i fattori epigenetici individuali, come sostiene anche Silvio Garattini Fondatore dell’Istituto Mario Negri di Milano punto di riferimento della Farmacologia e più in generale di tutta la Sanità in Italia.
Malattie come arteriosclerosi, infarto del miocardio, ischemie, tumori (cancro polmone, mammella, colon) malattie metaboliche, diabete di tipo2, broncopneumopatie ostruttive, malattie neurologiche come Alzheimer, Parkinson, demenza senile possono essere evitate e contrastate conferma Silvio Garattini con una adeguata prevenzione che può evitarne le complicanze anche attraverso una “Medicina di Precisione” conosciuta come medicina personalizzata o genomica personalizzata che rappresenta un pilastro fondamentale nell’evoluzione della cura della salute per tutte le persone.
Questo approccio emergente combina dati genetici e genomici con i fattori clinici e ambientali che relazionano con i diversi impatti del microbioma umano e con le caratteristiche legate al genere, approccio che consente di valutare in modo accurato i rischi individuali e di personalizzare le strategie, le diagnosi, prevenzione e gestione delle malattie.
I progressi compiuti dalla ricerca scientifica e dalla clinica negli ultimi 10/15 anni grazie a studi e ricerche internazionali di grande rilevanza scientifica come “l’International Human Genoma Project” valorizzato da Francis Collins Direttore dello Human Genoma Research Institute (USA) e padre del genoma umano, a cui si deve il completamento della mappatura dell’intero codice genetico umano racchiuso in tre miliardi di lettere del DNA che insieme alle acquisizioni più recenti di un ulteriore progetto scientifico denominato “International Human Microbioma Project” hanno offerto sempre più preziose informazioni basate sulla caratterizzazione completa del Microbioma Umano attraverso il sequenziamento mirato del 16rRNA (Ribosoma RNA) batterico e il sequenziamento dell’intero genoma microbico attraverso la conoscenza sempre più approfondita delle scienze omiche come la trascrittomica microbica, la metabolomica e la proteomica.
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As A Outcome Of HGH is a naturally occurring protein within the physique, it’s one
of the harder PEDs to detect in doping checks.
This helps enhance the muscle-to-fat ratio while lowering recovery times so your downtime between exercises
is lowered. As HGH can also be useful for a variety of other well being features, there’s the potential
for improvements in skin health and advantages for bone strength, mind and organ well
being, sleep high quality, and mood. Depending on your particular objectives, these will typically be
the preferred steroids, like testosterone and Trenbolone for bulking cycles
and Anavar or Winstrol if you’re on a slicing cycle.
For essentially the most hardcore fats loss, Clenbuterol (which just isn’t a steroid) is typically stacked with HGH.
Deca Durabolin and Anadrol are different steroids that males will stack with HGH.
HGH is such a novel substance for efficiency and/or other well being benefits that it could not (and ought to not)
be instantly comparable to anabolic steroids, SARMs, or most different PEDs.
Very few information support the concept that
HGH helps folks with normal ranges. Utilizing them for any nonmedical cause is in opposition to the law in the Usa.
They are thought of performance-enhancing medication and are banned in skilled sports activities.
The skin space can also be affected and should turn thick,
coarse, and furry. The extra HGH levels can even lead to high blood
pressure and heart illness. People with acromegaly will experience an overgrowth of
bones, particularly within the palms, feet, and face.
Surgery or radiation may be necessary to deal with a tumor in the pituitary.
This web site doesn’t promote any type of medical remedies or
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We could discuss different manufacturers’ statements relating to their legal natural herbal supplements, however you will need to
acknowledge that these products are not approved by the FDA.
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Of course, essentially the most prominent element to
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Substances similar to Human Progress Hormone or anabolic steroids merely
serve to amplify the efforts and hard work that the vitamin and training elements have
correctly established. Human Development Hormone
doses are very specific when it comes to what each
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etc.). Regulatory agencies, such because the WADA and the IOC, regulate
performance-enhancing substances in sports activities, together with bodybuilding.
These companies play a important function in making certain fair competitors and protecting the health of athletes [37].
WADA was established in 1999 and is answerable for promoting,
coordinating, and monitoring the struggle towards doping in sports activities.
Hold in thoughts that buying unlawful substances
additionally hide a threat that they may contain chemical and biological contaminants.
Steroids are available two major types – pills and intramuscular injections.
Due to the fat-soluble nature of all anabolic steroids, they are
well absorbed in the digestive system.
Most bodybuilders use Human Progress Hormone
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However, there isn’t any scientific proof that this
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the expansion hormone does not cut back the
operate of the pituitary gland. Additionally, long-term use of huge quantities of HGH can result
in permanent unwanted effects, such as acromegaly, after years
of misuse. For the athlete, Somatropin is a very valuable compound although not generally
one that’s used alone.
Please notice that the variations, benefits, and drawbacks
cancel out a method or one other. For the
easy reason that each HGH and steroids are quite versatile with options
unique to every. In comparison, steroid hormones have a
typical molecular structure consisting of 4 rings
manufactured from 17 carbon atoms. This construction resembles
the one of ldl cholesterol, as all steroid hormones are produced from it.
In reality, HGH is an entirely different hormone in nature compared to steroids – it has a different structure,
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Instead, its purpose is to deal with the symptoms of progress hormone deficiency,
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HGH binds to somatropin receptors, while IGF-1 binds to insulin and
IGF receptors. This reinforces the reality that whereas the
consequences of those two drugs are completely different they’ll work synergistically.
It can contribute to exercise positive aspects but can’t be an different to exercise.
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