MEDICINA DI PRECISIONE: “Le malattie croniche non trasmissibili”
400 mila decessi registrati ogni anno: l’allarme degli esperti per il progressivo aumento delle malattie in Italia
Sovrappeso, obesità, consumo di tabacco, consumo eccessivo di alcool, inattività fisica sono i fattori di rischio e la principale causa delle Malattie Croniche non Trasmissibili (MCNT) che rappresentano un grave problema per la salute pubblica in Italia.
Le Malattie Croniche non Trasmissibili (MCNT) sono malattie croniche multifattoriali che dovrebbero rappresentare la priorità assistenziale per il sistema salute di un paese civile, le malattie cardiovascolari, tumori, malattie respiratorie, infarto del miocardio, malattie neurologiche sono da anni la principale causa di morte in Italia e sono in continuo aumento.
Secondo la Società Italiana Educazionale Medicina di Precisione riferisce il Presidente Augusto Sannetti i fattori che influenzano negativamente sull’emiciclo dello sviluppo delle Malattie Croniche non Trasmissibili (MCNT) sono da individuare in Italia sicuramente quale conseguenza di una insufficiente concertazione delle strategie e politiche sanitarie di contrasto e di iniziative e di programmi educazionali intesi a limitarne le cause determinanti comeuna scorretta alimentazione, una insufficiente attività fisica, l’eccessivo consumo di alcolici e dipendenza al fumo e droghe, oltre che da un insufficiente controllo e monitoraggio di queste malattie e palese carenza di cure efficaci e sicure che devono essere realizzate secondo i canoni della Medicina di Precisione ancora in Italia poco conosciuti.
Le Malattie Croniche non Trasmissibili (MCNT) rappresentano quindi un argomento di grande attualità sia per le nuove strategie terapeutiche che per le politiche sanitarie necessarie che spettano al SISTEMA SANITARIO NAZIONALE attraverso un PIANO NAZIONALE DI PREVENZIONE che dovrebbe esserepiù credibile nella sorveglianza e nel monitoraggio nella lotta contro tale emergenza sanitaria e più attendibile ed incisivo nell’offrire opportunità formative ai medici specialisti in generale, per creare competenze operative da mettere in pratica per produrre risultati clinici assistenziali al fine di proporre diagnosi precoci e corrette e terapie sicure ed efficaci.
Per queste ragioni una “Medicina di Precisione”, risulta essere sempre più importante per limitare la deriva delle distorsioni cliniche scientifiche di una medicina generalista o gross medicine, ancora prevalente in Italia che continua a produrre diagnosi tardive talvolta errate ed ingannevoli che vengono ancora proposte per ignoranza concettuale o per interessi economici sottostanti con cure inadatte soluzioni inefficaci e terapie farmacologiche non corrispondenti secondo i principi di precauzione medica che producono in Italia circa 12 mila morti l’anno per antibiotico resistenza e oltre 40 mila morti all’anno per gli effetti avversi ai farmaci.
Il Presidente della Società Italiana Educazionale Medicina di Precisione identifica tra i fattori e le cause che producono i più frequenti errori di pertinenza medica l’assenza di una capacità di processualità storico amnestica da parte del medico che implica una visione sistemica dello stato di salute bio-fisico-sociale-transgenerazionale e di genere definibile come FILO-ONTO-EPIGENESI-SISTEMICA che impone una conoscenza della farmacogenomica e della nutrigenomica e delle scienze omiche come metabolomica, genomica, inflammosomica ed epigenetica che la maggioranza dei medici non conosce poiché non ancora materia di studio e di insegnamento nelle scuole di medicina.
Aggrava il problema poi quel deserto culturale e quella mancanza di conoscenza e comprensione necessaria del ruolo del “MICROBIOMA UMANO” sulla salute che la maggior parte degli operatori medici e degli ipotetici esperti di settore confondono ancora con il Microbiota, la cui alterazione viene contrastata con una massiccia dose di antibiotici, di antinfiammatori e più recentemente da integratori alimentari che una evidente distorsione medica e antiscientifica definisce con il nome di probiotici, postbiotici, psicobiotici etc, che sono dei potenziali perturbatori endocrini pro infiammatori che possono alterare il metabolismo individuale e che in molti casi possono produrre antibiotico resistenza. L’uso quindi degli integratori/probiotici è del tutto inutile per prevenire o contrastare gli effetti degenerativi le sintomatologie e gli effetti collaterali che accompagnano il mal funzionamento dei vari organi dei distretti dell’organismo umano che determinano le Malattie Croniche non Trasmissibili (MCNT).
Malattie come l’arteriosclerosi, broncopneumopatie ostruttive, obesità, allergie, alterazioni metaboliche, infarto del miocardio, ischemie e molte forme di tumore (cancro al polmone, colon, al seno, all’utero, prostata) patologie neurologiche e demenza senile possono essere evitate e contrastate con adeguata prevenzione che può evitare il cronicizzarsi delle malattie e ridurre in maniera significativa il numero enorme di decessi precoci e migliorare la qualità della vita di milioni di persone attraverso una “MEDICINA DI PRECISIONE” riconosciuta come una medicina personalizzata, o genomica personalizzata predittiva e preventiva che rappresenta un pilastro fondamentale nella evoluzione e cura delle Malattie Croniche non Trasmissibili (MCNT).
Le distorsioni scientifiche quindi che determinano i più frequenti errori iatrogeni devono essere contrastate e combattute poiché generano presso i pazienti cittadini una sfiducia di massa verso la scienza medica che compromette il prestigio e la fiducia nei confronti del medico che spesso viene percepito come un professionista assoggettato al consumismo imposto dalla pressione e pubblicità dell’industria farmaceutica e dagli interessi non neutrali dei farmacisti e di quelle speculazioni contraffattive e molto diffuse messe in atto da sedicenti esperti di settore che attraverso i social e i canali comunicazionali commerciali vantano efficacia, indicazioni terapeutiche, benefici di cure improbabili e non veritiere né validabili scientificamente, derivanti dalla commercializzazione di farmaci, di integratori alimentari e più specificatamente di quelli che con evidente alterazione scientifica/etimologica vengono definiti probiotici, postbiotici, psicobiotici etc.
Altro fattore da osteggiare è quella consuetudine di alcuni opinion leader medici che a sostegno degli interessi dell’industria farmaceutica si prestano a produrre relazioni, presentazioni, comunicazioni scientifiche, enfatizzandole come novità originali ma che in realtà non lo sono, tale pratica ricorrente è ben nota nell’ambiente medico scientifico riscontrabile nella maggioranza dei congressi delle varie specialità mediche, i cui partecipanti sponsorizzati dalle industrie farmaceutiche subiscono spesso una disinformazione scientifica addirittura certificata con crediti formativi che amplifica la distorsione scientifica influenzando poi la qualità delle cure e sicurezza dei pazienti.
Per queste ragioni, è nata la Società Italiana Educazionale Medicina di Precisione al fine di tutelare la salute fisica e psichica di tutte le persone attraverso una Medicina di Precisione e di Genere quale disciplina di insegnamento e di tutela della scienza medica presente e futura e di metodologia assistenziale e di controllo idoneo a monitorare la distorsione e le tendenze antiscientifiche al fine di contribuire e promuovere la salute e il benessere di tutte le persone attraverso una educazione medica e una corretta ed indipendente informazione efficace ed adeguata a contrastare quella non scientifica né basata sull’evidenza che possa risultare ingannevole per i consumatori ed i pazienti e fuorviante per la gestione clinica delle malattie e dei disturbi più frequenti come quelli derivanti dalle Malattie Croniche non Trasmissibili (MCNT) la vera emergenza sanitaria del XXI Secolo in Italia.
If you’re already at 10% body fats or much less, 5% can be a very extreme result.
At a naked minimum, the male physique needs a physique fat proportion of 2% for organs to perform correctly.
Anavar can contribute considerably to some lean features, but for male
customers, it’s very unlikely to be a reason for using this steroid.
Instead, the anabolic properties of Anavar are most valuable for men in phrases of
MAINTAINING muscle when losing fats. This steroid causes a
rise in pink blood cell manufacturing, which will get more oxygen to the
muscular tissues. One of the greater risks of oral steroids is
how they can stress the liver, doubtlessly inflicting liver injury or toxic hepatitis36.
Anavar has a modification to its chemical construction, generally identified as 17-a-alkylation modification, which allows us to make use of this steroid orally.
Anadrol could be helpful between chopping cycles to placed
on mass but would not often, if ever, be used in a dedicated chopping cycle.
Finally, we will work out for longer and get to the following
workout sooner with more environment friendly recovery.
You could use Sustanon when you choose on this cycle or your
individual choice of testosterone, but I advocate a fast ester if using injectables.
This is a really superior stack (both Tren and Anadrol could
be thought-about two of essentially the most potent AAS, including their sides).
Anadrol is only used for the primary three weeks, after which Trenbolone will help
dry out a few of that water weight.
We have seen Anavar add 10–15 lbs of muscle while considerably stripping fats (6).
Anavar is a mild steroid; due to this fact, the features customers expertise is not going to be remarkable, and the identical
applies to its unwanted side effects. With bodybuilders desirous to look as ripped
as attainable, trenbolone is a popular choice, as customers is not going to undergo from
clean, puffy muscle tissue or bloating. Loopy Bulk is
by far the most important legal steroids model on social media, with 11.9k followers on Instagram and 4.8k followers on Twitter.
The solely different noteworthy competitor on social
media was SDI Labs, with 2,994 Facebook followers, and Flexx Labs, with 1,
671 followers. Trenbolone, additionally known merely as
‘Tren,’ is considered one of the most popular steroids for speedy muscle features.
After per week of taking it, I started to experience explosive energy and shorter restoration times, making
my exercises far more productive.
What I love about Testo Prime is that it’s not nearly boosting testosterone.
It Is about creating an optimum hormonal environment for muscle progress,
fat loss, and total performance. I’ve seen clients
experience outstanding transformations – increased muscle definition, improved restoration instances, and a noticeable boost in vitality
and motivation. If you contemplate to purchase legal steroids on-line, better save your cash and think
of a greater managed substance, depending on your aim.
Like bulking steroids for muscle gain or cutting steroids for muscle definition. Your physical efficiency
is determined by what you taking and what effects you count on.
Steroids are additionally abused by athletes and bodybuilders to boost their efficiency and enhance their physiques.
However, when taken inappropriately, steroids could cause critical health issues
and are unlawful in most nations. One Other nice option is a reduce mix steroid,
which is a mix of multiple steroids designed for cutting.
Combining the primary and secondary compounds into a regular cycle
stack makes for a robust cycle. Still, depending in your experience level, you would possibly consider stacking more compounds for extra vital outcomes.
You have to know about the properties of every compound so you can decide
what advantages (and downsides) each will convey to the cycle and how totally different compounds can complement each other.
You may be wondering about typical doses for the primary compound in a standard cycle.
Nevertheless, a portion of this may be attributed to water retention that subsides post-cycle.Superior steroid users can eat dosages that exceed
one hundred mg per day; nonetheless, this presents
excessive levels of toxicity. This is important not just for health reasons but additionally to hold up the positive aspects you’ve
made during the cycle. Low testosterone will end result within the lack of muscle and the gaining of fats, primarily destroying
the onerous work you put in during the cycle.
During a Dianabol cycle, customers can count
on significant gains of seven to fifteen kilos of lean muscle mass—a outstanding achievement
that underscores the potency of this steroid.
Also, you won’t need the long-term HGH use on a 12-week cycle, but it helps improve positive aspects
in the course of the cycle (as are others like IGF).
Kickstarting a cycle includes making use of very fast-acting
compounds. Usually, this might be orals, but some short ester
injectables are also helpful. Since we’ll
normally use a slower-acting steroid (such as an enanthate or cypionate ester) as the primary compound
in a regular cycle, it’s a perfect cycle length to contemplate a
kickstart. Primobolan is also a DHT-derived steroid, and it’s an excellent one to use in lengthy cycles as it’s
a tolerable compound with reduced androgenic
results and milder testosterone suppression.
Testosterone is a bulking injectable generally utilized
in beginner cycles to add important bulk and mass to customers.
In contrast, injectable steroids are not considered hepatotoxic, having a extra direct passage into the bloodstream (via intramuscular
injection) and thus bypassing the liver. As we said, collagen peptides pose no
serious danger of common side effects.6 Solely people who are allergic to
collagen supplements — around 1-4% of the population7 — ought to outright keep away from them.
Nonetheless, you want to communicate with your physician before incorporating collagen into your supplementation regimen.
This ‘heating up’ of the body has been proven to be a really efficient approach
to burn fats. Clenbuterol technically isn’t a steroid; nevertheless, it’s typically mistakenly referred to as a
cutting steroid due to its powerful fat-burning effects. Bill’s expertise and expertise (plus our anecdotal findings) counsel that Anadrol may actually be
top-of-the-line steroids for girls, as 5 mg of Anavar is a tiny dose.
Furthermore, SHBG (sex hormone-binding globulin) is
a detrimental hormone to girls when elevated, as a end result of it releasing up extra active
testosterone. Anadrol, nevertheless, doesn’t bind successfully to SHBG receptors, and
thus ranges don’t rise considerably. One principle of why Anadrol is so well-tolerated by women is
that although it produces large will increase in testosterone, it also raises estrogen levels
significantly.
While some Steroids are typically more usually used for phases (Bulking and Cutting) the better thought is to use them for solving individual
problems! Running Estrogenic compounds when you already have blood pressure issues because “It’s Bulking season bro! DHB is extremely anabolic (5x that of Testosterone), and tremendous for strength.
Masteron can enhance your mood and mental outlook, which may help counteract a few of the opposed psychological results of Trenbolone. Possible side effects embrace low libido and erectile dysfunction if not used with testosterone, excessive ldl cholesterol, acne, head hair loss, gynecomastia, and insomnia. One of the difficulties in testing for anabolic steroids, as opposed to recreational drugs, is that hormones like testosterone and DHT are discovered naturally in the physique.
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So, when I see somebody reaching both with ease, it does increase an eyebrow.
This can additionally be why steroid use increases the danger of injuries,
as thinner pores and skin means that wounds don’t heal as fast as an individual
not using steroids. Anabolic steroids have an effect on collagen manufacturing in the body, which
makes the pores and skin thinner and more prone
to early growing older. As a results of thinner skin, the
veins are easier to identify as they are closer to the pores and skin’s surface.
Trenbolone Acetate can harm your liver and improve your possibilities of
developing prostate cancer. Trenbolone users may have
higher cholesterol and triglyceride ranges. Cardarine supplementation may be a danger till additional analysis is performed to determine its
effects. We have found that 500 mg/day of tauroursodeoxycholic acid (TUDCA) can scale back ALT and AST enzymes throughout Cardarine
cycles (Ma et al., 2016).
Amy, who has been working as an actress and in leisure for 20 years, explains that she is sweet at being discreet and protecting her pals.
However at the similar time, she says, she’s
witnessed so many people she cares about put their
our bodies via hell — countless workouts, diets calculated to the final fraction of a calorie, no nights out — for just a glimmer
of success in the industry. Pimples brought on by Trenbolone Enanthate is characterised by extreme congestion across
the chin and jawline.
Physique dysmorphia is a discussion we’ve been having culturally for
many years, however mostly as it concerns ladies and ladies.
Requirements of magnificence for the feminine physique have long been exacting and unrealistic.
One of the narratives surrounding well-known women’s bodies is on utilizing the synthetic —
plastic surgery, Photoshop, Instagram filters — to realize the unrealistic.
With men’s our bodies, the narrative is often that unrealistic outcomes are solely
a product of exhausting work. While David and Timothy’s
relationship was cultivated in particular person, it’s
not exhausting to search out the same conversations occurring
online. It occurs in Reddit threads, bodybuilding boards, and even Instagram
pages discussing PEDs. It’s gotten to the purpose where steroids
and other PEDs perform as memes.
For one hundred years, the Endocrine Society has been on the forefront of hormone science and public well being.
Learn about our historical past and how we
proceed to serve the endocrine community.
No, there is no way that you’re going to win a professional bodybuilding show without steroid use.
The major competitions – Mr. Olympia, Mr.
Universe, and the continental championships – are very aggressive, and the
principle competitors are all on steroids. Equally, natural bodybuilding physiques are far
more pleasing to many normal individuals.
To acquire muscle naturally, you have to improve your calorie consumption through bulking, which additionally leads to a rise in weight.
During my early coaching days, I was at all times fascinated by these with outstanding veins.
However it wasn’t till I discovered more about
steroids that I realized this extreme vascularity could be a telltale signal.
These pronounced shoulders, sometimes called ‘boulder shoulders’,
are characterised by their distinct 3D deltoid muscles—a robust indicator of steroid use.
Nonetheless, I’ve observed people at the fitness center who,
in just a matter of weeks, expanded in ways in which bordered on the supernatural.
On June 6, 2006, Arizona Diamondbacks aid pitcher Jason Grimsley’s house was searched
by federal agents. He later admitted to using human progress hormone, steroids, and amphetamines.
According to court docket documents, Grimsley failed a baseball drug check in 2003 and
allegedly named other current and former players
who additionally used medicine. On June 7, 2006, he was launched by the Diamondbacks, reportedly at his
personal request.
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References:
steroid stacks for Beginners (sinus.edu.pl)