Scoperta italiana rivoluziona il campo della Neuroinfiammazione: verso una medicina di precisione più efficace
Un team di scienziati italiani, in collaborazione con Harvard, ha identificato una nuova biomolecola che regola l’infiammazione e promuove la neuroprotezione. La scoperta sarà discussa al prossimo Congresso Nazionale di Medicina di Precisione, con l’obiettivo di rivoluzionare il trattamento di patologie complesse e croniche.
La Società Italiana Educazionale Medicina di Precisione a voce del Presidente Augusto Sannetti ha annunciato la recente scoperta ad opera di Scienziati e Ricercatori dell’Università degli Studi di Napoli “Federico II” e dell’Università degli Studi “La Sapienza” di Roma che in collaborazione con “Harward University” di Cambridge nel Massachusetts (USA) hanno scoperto una biomolecola endogena di segnale e fattore trascrizionale che regolando l’energia omeostatica del sistema immune è in grado di avere una interazione positiva sull’espressione dei geni up and down deregolati che producono infiammazione, dolore, infezioni e alterazioni metaboliche.
La biomolecola scoperta parte integrante del sistema immune è infatti un carrier del gene NAPE.PLD (N-ACIL-Fosfatidiletanolammina-Fosfolipasi-D) è utilizzata per la produzione endogena on demand di Palmitoiletanolamide che agendo direttamente attraverso il meccanismo ALIA (antagonismo locale contro il danno) sopprime la degranulazione dei mastociti attivando i ricettori PPAR-alfa e GPR5s e indirettamente i ricettori CB2 e CB1 svolgendocosì un ruolo determinante sul controllo e genesi dell’infiammazione e della neurodegenerazione.
La notizia già pubblicata su “International Journal of Molecular Sciences” è il risultato del lavoro di un prestigioso gruppo di ricerca Italianocoordinato dal Prof. Giovanni Sarnelli dell’Università “Federico II” di Napoli e dal Prof. Giuseppe Esposito dell’Università “La Sapienza” di Roma da sempre impegnati nello studio e nella ricerca della Neuroinfiammazione e della Neurodegenerazione.
Leggi tutto su Primapaginanews.it
Arabic
English
Italian
It’s really a cool and useful piece of information. I’m glad that you just shared this helpful info
with us. Please stay us informed like this.
Thank you for sharing. https://menbehealth.wordpress.com/
However, clenbuterol isn’t an anabolic steroid; therefore, we don’t
see it have an result on natural testosterone ranges to any vital
diploma. Trenbolone and Anavar may be stacked collectively during bulking or chopping cycles, resulting in considerable
fat loss and large features in muscle mass. However, because of the
presence of trenbolone, we contemplate this to be a harsh cycle and never
suitable for novices. We discover Anavar peaks quick within the bloodstream because of its brief half-life of 9–10 hours.
In our experience, customers generally notice an enchancment in physique composition throughout the first two weeks.
If you’re getting high quality oxandrolone, you’ll
love the stable, dry positive aspects. Despite the above protocol being efficient, DHEA is
the official medical treatment prescribed to girls for low
androgen levels.
Folks diagnosed with eczema or psoriasis, could
expertise a rebound impact of their signs (sometimes severely) if
they suddenly cease using even a strong topical steroid.
Signs that rebound can also happen with numerous conditions,
including sciatica treated with steroid injections.
Rapid withdrawal of steroids might trigger a syndrome that would embody fatigue, joint pain,
muscle stiffness, muscle tenderness, or fever.
This may embrace ordering a blood take a look at to measure
the level of potassium in your blood. If it’s low, your physician can suggest an appropriate therapy.
Earlier Than starting prednisone treatment,
you might wish to speak along with your doctor about
your threat of side effects and what dose is best for
you. With most instances, the discomfort of a flushed face or different steroid side effects will cross within a few hours or
days.
Your furry good friend’s health and well-being are price the additional effort and attention to detail.
Trends in using steroids in canine have developed over the years,
with extra pet house owners choosing different treatments
to keep away from the potential unwanted facet effects of those
medicines. One development that has emerged is using holistic and pure
remedies to handle conditions that may traditionally be handled with steroids.
This shift in path of pure treatments reflects a growing concern among pet owners about the long-term results of steroids on their canines’ health.
Nevertheless, if a person predominantly desires to burn fat on Anavar, then a
small calorie deficit may be carried out to speed up fats loss whereas aiding muscle retention. Cardiovascular train, or HIIT (high-intensity interval training), can also be utilized to accelerate a user’s metabolism whereas
offering cardiac advantages. If a consumer is stacking Anavar with harsh
compounds, they may incorporate the above protocol.
However, if a person makes use of an Anavar-only cycle, taking certainly one of these PCT medication alone
is likely to be greater than enough in restoring endogenous testosterone manufacturing promptly.
Over half a century later, quite a few women have used Anavar anecdotally and
in analysis. Now it’s extensively thought of that doses in the vary of 5–10 mg produce
noticeable results while inhibiting virilization. When Anavar was initially
released available on the market, a common dose of
5–10 mg per day was frequent.
You don’t want to look hunched over like my old grandma earlier than your time.
So be certain to be taking calcium and vitamin D every day,
based on the doctor’s guidelines. For example, if you’re on a really high dose of prednisone and
your face will get puffier as time goes by and it’ll normally go away as soon as you’re beneath 10 milligrams or 5 milligrams.
Often the upper the dose, the more likely you’re to endure mental
well being side effects like anxiety, melancholy, paranoia, and simply actually not feeling like your self at all.
Whereas if you are only on a gradual, steady, low dose, your
body is so much nearer to its normal cortisol levels and it can generally recover faster.
– The user might choose to utilize a Prolactin-antagonist (AKA
a Dopamine agonist) similar to Cabergoline, Pramipexole,
or Bromocriptine.
Examples embrace taking nonsteroidal anti-inflammatory medication (NSAIDs).
Prednisone comes as a pill, delayed-release pill, as an answer (liquid),
and as a concentrated resolution to take by mouth.
Prednisone is usually taken with meals one to four occasions a day or as soon as
each other day. Your physician will probably let you know to take
your dose(s) of prednisone at sure time(s) of day every single day.
Your private dosing schedule will rely in your situation and
on the way you reply to treatment.
If the opposite numbers in the report are on track, breathe a sigh of aid and know all is properly.
Curiously sufficient, prednisone raises white blood cell counts on lab tests, Dr.
Hu stories. If you’ve a blood take a look at while taking prednisone, the outcomes could look abnormal.
Fluid retention can lead to a cascade of unfavorable effects in your well
being. “By teaming up along with your doctor and working towards good old-fashioned self-care, you’ll have the ability to decrease and even eliminate prednisone unwanted effects,” says household drugs physician Kevin Hu, MD.
Prednisone mimics cortisol and intercourse steroid hormones like
testosterone, estradiol, and progesterone. Healthcare providers use cortisone photographs to treat
irritation throughout your physique. They’ll inject
cortisone instantly into an area that’s experiencing inflammation. You ought to feel reduction from
symptoms around a week after your injection. If you experience continual irritation, you would possibly notice your signs returning progressively over
time. Speak to your healthcare provider if you discover new or
worsening inflammation.
Facet effects which will happen with short-term
use are sometimes much less extreme than those who occur with long-term use.
Corticosteroids (steroid drugs) are sometimes necessary and sometimes even life-saving treatments,
but they will have short-term side effects. For instance, steroids can typically cause a
flushed face for a number of days. They can also lead to long-term unwanted effects, a few
of them serious. Steroids are injected for the treatment of situations like carpal tunnel syndrome, bursitis, frozen shoulder, and inflammatory joint ailments like rheumatoid arthritis.
The steroids are injected directly into the affected joints or muscles.
Repeated injections can even trigger the skin on the site of injection to become permanently lighter in shade.
Awesome site you have here but I was wondering if you knew
of any forums that cover the same topics discussed in this article?
I’d really like to be a part of online community where I can get
advice from other knowledgeable people that share the same interest.
If you have any suggestions, please let me know.
Bless you!
350fairfax nordvpn
I like what you guys are up too. This type
of clever work and exposure! Keep up the awesome works
guys I’ve included you guys to my blogroll.